两个编码外显子和插入的内含子被删除,取而代之的是tau-GFP报告基因和一个由loxP序列标记的pgk-neo插入片段。随后与携带Tg(EIIa-cre)Lmgd的纯合品系杂交,这个cre系统会剪切掉neo选择性标记,从而获得一个能根据活性提供荧光标记的嗅觉感受器的GFP报告基因(来源:J:215302)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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