设计了一种靶向载体,其在exon 21上游插入了loxP位点,接着是含frt标签的诺卡因抗性基因(neo)区,随后是exon 21下游的第二个loxP位点。同时,exon 21上游的splice site 4被改造为标准的剪接接受序列。(来源:J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count