Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor

This transgene consists of the tetracycline response element, a chimeric receptor consisting of the Fgfr3 extracellular and transmembrane domains with the R248C mutation fused to the Fgfr1 tyrosine kinase domain and a c-myc tag. The R248C mutation in Fgfr3 confers ligand-independent constitutive activity. By fusing this mutant Fgfr3 receptor to the Fgfr1 tyrosine kinase domain, a receptor that constitutively activates Fgfr1 signaling in the absence of ligand is produced. Four lines were produced however the pound symbol (#) is used because the line is not specified. (J:211151)