在目标基因单个外显子的5'端引入了loxP位点,然后在3'端插入了FRT-loxP-(neo-tk)-FRT-loxP(LFNT)元件。通过Cre介导的重组,neo cassette被剔除,留下编码区域被loxP位点包裹。(来源:J:101977, J:211355)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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