这个条件性等位基因是通过飞蓬花酸1tm1a(EUCOMM)Wtsi敲除先驱品系通过flp重组酶介导的lacZ报告基因和诺卡因筛选 cassette的切除获得的。Cre重组酶的表达会导致小鼠敲除。有关此IKMC等位基因以及其他类似靶向策略的更多信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:236047)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count