这个条件性等位基因是通过飞蓬花酸1tm1a(EUCOMM)Wtsi敲除先驱品系通过flp重组酶介导的lacZ报告基因和诺卡因筛选 cassette的切除获得的。Cre重组酶的表达会导致小鼠敲除。有关此IKMC等位基因以及其他类似靶向策略的更多信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:236047)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
隐性
1
1
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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