通过Cre介导的父本Abca13tm1a(EUCOMM)Wtsi等位基因的去除,去除了由启动子驱动的诺卡因选择标记 cassette,以及关键的exon(或exons),留下插入的lacZ报告序列。欲了解针对此类IKMC等位基因以及其他类似策略的更多信息,请访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count