Nxf2tm1.1Jw/Y ES细胞通过电穿孔,用pUP108载体构建了Igs8tm1Jw突变,该突变替换小鼠X染色体上Tmsb15a和Armcx5之间一个5.6kb的非基因间隔区,插入了含四条loxP位点的floxed PGK-neo筛选 cassette,形成一个条件性修饰基因。随后,这些含条件性突变的个体与Actb-Cre小鼠杂交,以删除Nxf2和Tmsb15a之间782kb的X染色体区域。(来源:J:210663)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因间区删除,基因内删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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