在第1外显子被替换为经过修改的第1外显子,其中A替换为T导致了起始翻译位点的破坏。通过Flp介导的重组,去除了插入在修改第1外显子下游的FRT标记的诺卡因抗性基因座。 Western blot结果显示,大脑中没有检测到e1亚型的表达,而e2亚型的表达保持不变。(来源:J:209069)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
Insertion, Single point
--
1
15
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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