在exon 8的上游插入了一个loxP引导的诺姆西林插件,并在 intron 8中加入了一个第三个loxP序列。通过Cre介导的重组酶,去除了诺姆西林插件。去除exon 8会导致框架移位的突变,产生部分缺失的蛋白质。(来源:J:212048)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
8
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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