Scn8a^em1Mm

TALEN technology was used to generate an A to G point mutation in exon 26 that results in the amino acid substitution of aspartic acid for asparagine at position 1768 (N1768D). Seven more synonymous changes within the TALEN binding sites were introduced to minimize redigestion of targeted allele. 62 founders were identified with 13 distinct insertion/deletions in 24 mice. (J:207931)