这个靶向载体包含从5'到3'的序列:一个剪接接受器、内含子(IRES)、Mer-Cre-Mer、牛生长激素的3' UTR,以及Frt-PGKneo-Frt的元件。MerCreMer双融合蛋白由带有突变的雌激素受体(mer)配体结合区域(281-599,G525R)的Cre重组酶cDNA序列在两端包覆,使得Cre表达对托莫西汀诱导,但对雌激素不敏感。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129
Targeted
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
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