在5'端插入了带有FRT标记的lacZ/neo构建,同时保留了一个loxP位点,位于5号外显子上游。接着在5号外显子的3'末端保留了一个loxP位点。随后通过表达flp重组酶,移除了5'选择 cassette。之后通过cre表达,剪切掉了5号外显子。(来源:J:206155)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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