Exon 3被替换为包含3到11号外显子的人类cDNA,通过Flp介导的重组去除了筛选标记。随后,Cre介导的重组移除了人类cDNA。 Western blot结果显示睾丸、附睾、尾部精子和肝脏中没有蛋白质表达。(来源:J:210360)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
2
15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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