这个转基因包含了带有两个点突变(506位的G变A,518位的A变C)的murine Prnp微基因,这些突变影响了球状域的结构。由此产生了名为rigid loop Prnp的鼠- elk融合蛋白。这条转基因小鼠约有45个拷贝,大脑中表达的量大约是野生型水平的2-3倍。(来源:J:143528)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
B6;129S7-Prnptm1Cwe
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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