Tas2r131编码区域被替换为一个表达载体,它包含巴麦芽糖凝集素(BL)序列,通过内源性核糖体进入序列与Cre重组酶序列相连。BL序列的79位和597位位置插入了Flag和c-myc抗原决定簇,用于不同类型的突触追踪。此外,还插入了一个AFN(tatACE-Flpe/NEOr)的诺卡因选择性 cassette,前后有FRT座点。通过与Flpe-deleter杂交,可以消除诺卡因选择性 cassette。这个等位基因是Tas2r131的无功能型,从Tas2r131启动子产生BL和Cre的双顺式转录本。(来源:J:200616, J:209852, J:309106)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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