通过Cre介导的父本Cul5tm1(KOMP)Vlcg等位基因的去除,去除了新霉素选择座,并通过删除了关键的exon2到6,剩下插入的lacZ报告序列。欲了解针对此类IKMC等位基因的其他靶向策略,请访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count