这个靶向载体插入了a位置的CAG启动子,包含一个2.7kb的诺卡因抗性/终止子 cassette,优化了的秀丽隐杆线虫的谷氨酸门控氯离子通道(alpha和beta基因由TaV 2A序列分隔),第二个TaV 2A序列,以及EYFP基因和木鼠肝炎病毒的后转录调控元件(WPRE)。要实现表达,需要Cre介导的重组。(来源:J:206513)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N
Targeted
插入
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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