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在第19内含子和第20外显子的838位由TAT变为TAC，通过同源重组插入了反向剪接的pgk-neo cassette。这导致了D838Y的变异，与急性髓系白血病患者中观察到的D835Y突变相同。通过Cre介导的重组，neo cassette被去除了。(来源：J:205200)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
