这个Adad2-5594J-B项目中的等位基因是在Jackson实验室通过将Cas9 RNA和引导序列CCCATGCTCAGCGGTCCTAG注入产生的,导致了8个碱基的缺失(CTAGGACC)以及4个碱基的插入(ATGA),发生于8号染色体正链位置119,612,902bp(GRCm38),预测会导致frameshift突变和早期截断。 (来源:J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
插入,基因内删除
不确定
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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