Log In|Sign Up
中文
这个转基因包含了12kb的mouse Prnp启动子区域，包括内含子1，接着是野生型mouse Prnp的cDNA。转基因中还包含了一个3F4单克隆抗体的表位标签。E1品系的半合子小鼠携带有9个这种转基因构建，通过定量Southern blot分析确认。使用3F4抗体对脑匀浆进行 Western blot分析，结果显示突变型prion蛋白的表达量是内源性hamster PrP的1.8倍。（来源：J:51891）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
