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中文
一个包含整个色氨酸脱羧酶(Hdc)基因的BAC(RP24-14N14)在细菌细胞中被改造，替换Hdc基因的第2外显子起始的47个氨基酸、1个内含子和1个外显子，插入了Cre重组酶编码序列、SV40polyadenylation信号和Frt标记的kanamycin抗性元件。通过Flp重组，去除了kanamycin标记。经过核内注射验证的构建产生了奠基小鼠。产生了多个奠基小鼠。其中一只奠基小鼠被确认携带有转录基因，并在中枢神经系统中表现出预期的Cre活性。(来源：J:194386)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
