在exon 2上游插入了一个带有5' loxP位点的诺美西林抗性基因座,然后在exon 2下游又插入了一个loxP位点。通过Cre介导的重组,这个选择性基因座和exon 2都被去除了。实时定量PCR确认了在小鼠胚胎成纤维细胞中转录表达的缺失。(来源:J:207884)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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