这个构建包含了TRE3G(第三代tet响应驱动子),EmGFP区域(Mirlet7a与修改过的mir155尾部环的融合),一个SV40polyadenylation信号,13kb的mouse Vil1启动子,以及rtTA-M2序列。Mirlet7a/mir155融合的shRNA不被LIN28A或LIN28B识别。(来源:J:202923)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count