靶向载体设计为在exon 2上游插入一个loxP位点,接着是含frt标签的诺卡因抗性(neo)基因座,然后在exon 2下游再增加一个loxP位点。通过与Tg(CMV-cre)1Cgn小鼠杂交,产生了突变小鼠,以去除包括exon 2在内的含loxP的区域。(来源:J:207523)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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