最终外显子被一个loxP位点和一个3'端有FRT标记的诺卡因抗性基因座(带有loxP序列的FRT-flanked neomycin resistance cassette)所 flank。通过Cre介导的重组,这个选择性基因座和最终外显子被移除。 Western blot结果显示,E12.5期胚胎中没有蛋白质表达(来源:J:206541)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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