在第一PDZ域的羧端编码区域和第二个PZD域氨基端的外显子上游插入了loxP位点,接着在该外显子下游插入了带有3' loxP座的诺卡因抗性基因座(FRT-flanked),通过Flp介导的重组移除了选择性标记。随后,Cre介导的重组剔除了这个外显子。(来源:J:202688)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count