带有双向CMV启动子的四环素应答元件驱动对人类MAPT(TauRD, 244-372aa)中携带17号染色体Lys280缺失(ΔK280)的前额叶-颞叶痴呆和帕金森病相关四重复区的诱导表达,以及一个荧光素酶基因。Lys280缺失会加速MAPT( Tau)的聚集。(来源:J:131379)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
IF
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