带有双向CMV启动子的四环素应答元件驱动对人类MAPT(TauRD, 244-372aa)中携带17号染色体Lys280缺失(ΔK280)的前额叶-颞叶痴呆和帕金森病相关四重复区的诱导表达,以及一个荧光素酶基因。Lys280缺失会加速MAPT( Tau)的聚集。(来源:J:131379)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count