L1L2_Bact_P cassette被插入到染色体2的156,971,510位置,位于关键exon2的上游(基于GRCm39构建)。该 cassette包含FRT位点、lacZ序列和一个loxP位点。FRT位点后面跟着由人类β-actin启动子驱动的诺卡因抗性基因、SV40polyA,然后是第二个FRT位点和第二个loxP位点。第三个loxP位点被插入在目标exon2下游,位置为156,972,268。因此,关键exon2被loxP位点所夹峙。通过Flp介导的重组,捕获cassette被移除,exon2被标记为可翻转。(来源:J:202757)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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