通过Cre介导的父本Slc25a21tm1a(KOMP)Wtsi基因座去失,删除了由启动子驱动的诺卡因选择标记片段,保留了插入的lacZ报告基因序列。有关这种IKMC等其他基因座靶向策略的更多信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count