通过Cre介导的父本Cyb5r2tm1a(EUCOMM)Hmgu等位基因的去除,去除了由启动子驱动的诺卡因选择标记片段,以及关键的内含子,保留了插入的lacZ报告序列。欲了解针对此类IKMC等位基因的其他靶向策略详情,请访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count