在exon 2上游插入了FRT-和loxP引导的诺卡因抗性基因座,exon 2下游也插入了loxP位点。通过Flp介导的重组移除了诺卡因抗性基因座,随后Cre介导的重组去除了exon 2。反转录PCR证实了骨组织中没有转录表达。(来源:J:201631)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NTac x 129S6/SvEvTac)F1
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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