一种自我剔除的诺霉素抗性基因座替换了Duoxa2基因exon 5至Duoxa1编码exon 5的2857bp区域。最终等位基因去除了诺霉素抗性基因座。这些小鼠失去了基于DUOX的NADPH氧化酶活性。(来源:J:205329)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因间区删除,基因内删除
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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