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中文
在包含NLS-cre-polyA序列（核定位信号-Cre重组酶-polyadenylation信号）的载体的5'端插入了loxJTZ17位点。在靶向构建的3'末端插入了PGK-puromycin选择子 cassette和lox2272位点。在已含Spink3tm1Kymm插入点的ES细胞中，实现了Cre cassette位于Spink3基因exon 1上游，替换了neo标记。通过正确靶向的ES细胞克隆产生了嵌合体，然后通过与C57BL6/J动物的杂交建立了遗传传递。(来源：J:205182)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
