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中文
在目标基因的第四外显子中，通过同位素诱变技术将第358位的甘氨酸替换为色氨酸(GGC->TGG，即第1069和1071位的鸟嘌呤替换为胸腺嘧啶和胞嘧啶替换为鸟嘌呤)，实现了这一改变。同时，一个含loxP序列的诺卡因选择性载体被插入到第3内含子。随后，Cre酶介导的重组移除了含loxP的诺卡因 cassette。参考文献：(J:204960)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
