基于TALEN的基因组编辑,目标序列是5'的TCCTACAGCTCTTCCACG和3'的TCACCCAGGGAGCCTCCG,用于在exon 50插入一个10个碱基的frameshift删除。这种变异预计会导致功能不正常的蛋白质。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因内删除
--
1
11
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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