这个靶向构建引入了位于一个剪接接受序列的位点,包含了一个带有四倍polyadenylation序列的敲除诺卡因抗性终止子(Neo cassette),融合了人TMPRSS2(exon 1)和ERG(exon 4),带有内含子(IRES),核定位的人绿色荧光蛋白(EGFP)以及polyadenylation序列。(来源:J:200002)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129
Targeted
插入
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8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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