Cre介导的重组发生在MHPP256h04(13:78,918,316; MM9)和MHPN5k06(13:79,454,030; MM9)这两个MICER克隆之间,目标是恢复功能正常的Hprt基因,并产生一个包含535Mb的大缺失区域,这个区域与大鼠乳腺癌易感性位点Mcs1a的同源区域相同。(来源:J:199158)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion, Intergenic deletion
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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