Ccdc88b^m1Pgrs

ENU mutagenesis induced a T to C mutation in the splice donor consensus site of exon 21; Chr19: 6,848,180 (- strand) (build NCBI38/mm10). The point mutation results in a 5 nt deletion in the transcript and a frame-shift with a predicted premature termination at codon 1286. Western blot analysis confirmed the absence of protein expression in the spleen, thymus, lymph nodes and kidney. (J:230618)