带有第10外显子无义突变的条件性Trp53基因等位体,与Tg(Pgk1-cre)1Lni小鼠杂交,目的是剔除含终止子的片段。由此产生的等位基因产生编码缺少最后31个氨基酸(C末端域,CTD)的Trp53蛋白的mRNA。来源:(J:199308)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Single point
--
1
65
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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