在催化活性的exon 7的111个碱基编码区域,替换为一个终止密码子、内含子启动子序列、lacZ报告基因和FRT标记的诺卡因抗性元件。通过Flp介导的重组移除了诺卡因抗性元件。 Western blot结果显示大脑( cerebellum)和前脑(forebrain)中没有蛋白表达。(来源:J:201327)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
插入
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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