在exon 2的上游插入了loxP511位点和loxP位点,而在exon 3的下游则插入了FRT引导的neo cassette、loxP位点和loxP2722位点,通过同源重组实现。通过重组酶介导的重组,neo cassette和exons 2、3都被移除,剩下loxP511、loxP以及loxP2722位点。这个等位基因设计用于允许通过重组驱动的 cassette 交换。(来源:J:199462)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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