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中文
使用BAC重组技术构建的靶向载体，通过同源重组在B6衍生的ES细胞中，将Notch1的内源性域(N1ICD)替换为Notch2的内源性域(N2ICD)，编码1705到2473的氨基酸序列。Notch1的3' UTR未改变，以保持mRNA的稳定性。当这个突变基因型成功传代至生殖系后，靶向载体中引入的Frt标记被通过与翻转酶缺陷小鼠杂交去除。(来源：J:198632)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
