使用重组修复技术对BAC(RP23-357E17)进行修改,其中包含Krt17基因。插入了带有IRES-cre/ERT2启动子-选择标记和FRT定位的neo标记。随后通过转录后切口酶(Flippase)移除了neo标记。纯化后的构建被注入到受精卵中。产生了两个阳性克隆,1F3和1F4。来源:(J:199315)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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