在Mir212的上游插入了一个loxP位点。在Mir132的3'端插入了一个FRT标记的诺卡因抗性 cassette,它自身带有1个loxP位点。通过Flp酶介导的重组,去除了诺卡因抗性 cassette,使得两个microRNA成为可靶向的。随后,通过Cre介导的重组,移除了这两个microRNAs。(来源:J:200865)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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