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中文
在7号外显子上游插入了floxed neo/Tk选择座，下游则插入了第三个loxP位点。通过短暂的Cre表达，对靶向的ES细胞中，这个选择座和7号外显子被成功剔除。敲除小鼠的胰岛中未检测到蛋白质和mRNA（来源：197386）。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
