构建了一个靶向载体,用于将带有3'β-珠蛋白poly(A)末端和loxP介导的PGK-诺瓦克林筛选 cassette插入第2外显子,替换整个编码序列。通过Cre介导的重组,去除了诺瓦克林筛选 cassette。(来源:J:101977, J:139151)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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