通过同源重组,cre/ERT2-IRES-EGFP cassette被插入tenascin C基因的第二个外显子,紧接在起始密码子ATG之后。随后是一个由frt座点 flank的neo选择标记。在没有使用Tamoxifen治疗的情况下,EGFP的表达与肾内髓质间质细胞的内源性Tnc表达相似。在没有Tamoxifen的情况下,未观察到显著的cre依赖性报告活性。(来源:J:202522)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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