Ryr2^tm2.1Msnr

Exon 75 was replaced with a modified exon 75 in which nucleotide substitutions result in the amino acid substitution of aspartic acid for leucine at position 3591 (L3591D). This mutation eliminates CaM and S100A1 inhibition at diastolic Ca2+ ions only. A self-excising neomycin resistance cassette inserted dowsntream of the modified exon 75 is excised from the final allele. (J:200958)