Ptpn22^tm1.1Draw

Exon 14 was replaced by a modified exon 14 in which a point mutation (C to T) results in the amino acid substitution of a tryptophan for arginine at position 619 (R619W). The mutation is analogous to the human disease-linked variant (LYP-R620W). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modifies exon 14. Western blot analysis confirmed normal protein stability. (J:201448)