Exon 14被替换成一个带有floxed Neo抗性基因座的序列,以及一个修改过的Exon 14,其中去除了669WTAPELL675这个关键区域。这个区域对于心房钠尿肽信号的传导至关重要。随后,通过Cre介导的重组,删除了Neo抗性基因座。(来源:J:201932)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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